The main focus is on peripheral neuropathies and neuropathic pain. Severity varies, but patients most commonly have significant life-long disability. There is an active programme of gene discovery, mouse model phenotyping and translational research the main aim of which is to gain a better understanding of the response of the peripheral nervous system to injury in order to develop strategies to promote peripheral nerve repair and to prevent the development of neuropathic pain. An important consequence of neural injury is altered signalling between neurons, glia and immune cells. We are investigating the molecules mediating such signalling and their role in neural repair and altered sensory processing.