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Motor Neuron Disease (MND) is a progressive neurodegenerative disease that dramatically shortens the lives of the majority of those who develop it because there is no effective disease-modifying treatment as yet. It causes relentless weakness in the limbs and often speech and swallowing muscles, with loss of independence and eventual respiratory failure. Those who develop MND have typically led healthy, active lives, and only a minority have a family history ofthe disease or the related condition frontotemporal dementia (FTD). Amyotrophic lateral sclerosis (ALS), the commonest form of MND and the third commonest form of neurodegenerative disease after Alzheimer’s and Parkinson’s, is currently incurable.

Groups

Suzan Hammond: Neuromuscular Translational Research

Carlo Rinaldi: Neuromuscular Translational Research

Laurent Servais: Specialised Translational Research Oxford Neuromuscular Group

Kevin Talbot: Oxford Motor Neuron Disease Centre

Martin Turner: FMRIB Neurodegeneration Group

Matthew Wood: Nucleic Acid Gene Therapy in Brain and Muscle